生物活性
BLZ945是有效的选择性CSF-1R激酶抑制剂。它减弱了TAM的周转率，同时增加了浸润宫颈癌和乳腺癌的CD8+ T细胞的数量。
靶点信息
化学数据
| 目录号 | A15540 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 398.4 |
| Formula | C20H22N4O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 953769-46-5 |
| Synonyms | BLZ 945, BLZ-945 |
| SMILES | CNC(=O)C1=NC=CC(=C1)OC2=CC3=C(C=C2)N=C(S3)NC4CCCCC4O |
溶解度
| In vitro (25°C) | DMSO | 77 mg/mL (193.23 mM) |
| Water | Insoluble |
| Ethanol | Warmed: 3 mg/mL |
| In vivo | 4% DMSO+30% PEG 300+ddH2O | 2.3 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 25.1 mL | 125.5 mL | 251 mL |
| 0.5 mM | 5.02 mL | 25.1 mL | 50.2 mL |
| 1 mM | 2.51 mL | 12.55 mL | 25.1 mL |
| 5 mM | 0.5 mL | 2.51 mL | 5.02 mL |
*The above data is based on the productmolecular weight 398.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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