Abacavir hydroxyacetate 是一个具有口服活性的 IL-20 和 PRINS 的抑制剂。Abacavir hydroxyacetate 作为免疫调节剂，降低牛皮癣的增殖率。Abacavir hydroxyacetate 可用于炎症型皮肤病的研究。
| Cas No. | 1446418-48-9 |
| 分子式 | C16H20N6O3 |
| 分子量 | 344.37 |
| 溶解度 | DMSO : ≥ 100 mg/mL (290.39 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Abacavir hydroxyacetate is an orally active inhibitor ofIL-20andPRINS. Abacavir hydroxyacetate reduces proliferation rate of skin in psoriasis as an immune modulator. Abacavir hydroxyacetate can be used for the research of inflammatory skin problems[1][2]. Abacavir hydroxyacetate (10-20 mg/kg; p.o. once) effectively controls psoriasis of mice[2]. | Animal Model: | 6 to 8-week-old male and female SCID mice with implantation of psoriatic tissue[2] | | Dosage: | 10 and 20 mg/kg | | Administration: | Oral gavage; 10-20 mg/kg once | | Result: | Decreased the concentration of PRINS and 1L-20, and reduced the lesion area of skin. Showed a better effect than methotrexate in controlling psoriasis. |
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