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Argipressin(acetate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Argipressin(acetate)图片
CAS NO:129979-57-3
包装:1mg
市场价:832元

产品介绍
A peptide hormone with vasoconstrictive and antidiuretic activities
Cas No.129979-57-3
别名精氨酸加压素
Canonical SMILESN[C@@H](CSSC[C@@H](C(N1CCC[C@H]1C(N[C@H](C(NCC(N)=O)=O)CCCNC(N)=N)=O)=O)NC([C@H](CC(N)=O)N2)=O)C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCC(N)=O)C2=O)=O)=O)=O.CC(O)=O
分子式C46H65N15O12S2·XC2H4O2
分子量1084.2
溶解度Water: 1 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Argipressin is a peptide hormone with vasoconstrictive and antidiuretic activities that binds to the vascular arginine vasopressin receptor, V1, with Kdvalues of 1.31 and 1.44 nM in A7r5rat aortic smooth muscle cells and neonatal rat cardiomyocytes, respectively.1,2It also stimulates the intracellular release of calcium in A7r5cells (EC50= 5 nM).3In rat models, argipressin induces hypertension and tachycardia when injected into the lateral septal nuclei at a dose of 100-400 ng and increases heart rate and mean arterial pressure (MAP) when injected into the medial amygdaloid body at a dose of 150-600 ng.4,5

1.Thibonnier, M., Bayer, A.L., Simonson, M.S., et al.Multiple signaling pathways of V1-vascular vasopressin receptors of A7r5 cellsEndocrinology129(6)2845-2856(1991) 2.Xu, Y.J., and Gopalakrishnan, V.Vasopressin increases cytosolic free [Ca2+] in the neonatal rat cardiomyocyte. Evidence for V1 subtype receptorsCirc. Res.69(1)239-245(1991) 3.Byron, K.L.Vasopressin stimulates Ca2+ spiking activity in A7r5 vascular smooth muscle cells via activation of phospholipase A2Circ. Res.78(5)813-820(1996) 4.Gao, L., Jiang, N.-C., Luo, Q.-H., et al.Cardiovascular effects of injection of argipressin into lateral septal nuclei in ratsZhongguo Yao Li Xue Bao.17(1)49-52(1996) 5.Jiang, N.-C., Gao, L., Chen, C., et al.Effects of argipressin injected into medial amygdaloid body on blood pressure and heart rate in ratsZhongguo Yao Li Xue Bao.14(2)118-120(1993)