| CAS NO: | 26988-72-7 |
| 包装: | 50mg |
| 市场价: | 495元 |
| Cas No. | 26988-72-7 |
| 别名 | 1-甲基-色氨酸,1-Methyl-DL-tryptophan; (Rac)-NLG-8189 |
| Canonical SMILES | NC(CC1=CN(C)C2=C1C=CC=C2)C(O)=O |
| 分子式 | C12H14N2O2 |
| 分子量 | 218.25 |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes[1]. (Rac)-Indoximod (1-Methyl-DL-tryptophan; 0.5 mM; 3 days) inhibits tryptophan depletion, thereby partially reversing the growth-inhibitory activity of IFN-γ, but eventually induces cell death regardless of tryptophan depletion[1]. Cell Viability Assay[1] Cell Line: Human cardiac myofibroblasts (hCMs) [1]. Jun-Won Lee,et al. Co-treatment with interferon-γ and 1-methyl tryptophan ameliorates cardiac fibrosis through cardiac myofibroblasts apoptosis. Mol Cell Biochem. 2019 Aug;458(1-2):197-205. |
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