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ICCB280
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ICCB280图片
CAS NO:2041072-41-5
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
ICCB280是一种有效的C/EBPα诱导剂。ICCB280通过激活C/EBPα并影响其下游靶点(例如C/EBPε,G-CSFR和c-Myc),具有抗白血病特性,包括终末分化,增殖停滞和凋亡。
Cas No.2041072-41-5
别名(E)-2-(3,4-二羟基苯乙烯基)-3-(2-甲氧基苯基)喹唑啉-4(3H)-酮
Canonical SMILESO=C1N(C2=CC=CC=C2OC)C(/C=C/C3=CC=C(O)C(O)=C3)=NC4=C1C=CC=C4
分子式C23H18N2O4
分子量386.4
溶解度DMSO: 83.33 mg/mL (215.66 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets (such as C/EBPε, G-CSFR and c-Myc)[1][2].

ICCB280 (0.1-50 μM; 48 h) suppresses the HL-60 cell growth, with an IC50 of 8.6 μM[1].ICCB280 (10 μM; 2-8 d) increases the C/EBPα expression (mRNA and protein) and modulates its target genes in HL-60 cells[1].ICCB280 (10 μM; 7 d) induces granulocytic differentiation and subsequent apoptosis in HL-60 cells[1]. Cell Viability Assay[1] Cell Line: HL-60 cells

[1]. Radomska HS, et, al. A Cell-Based High-Throughput Screening for Inducers of Myeloid Differentiation. J Biomol Screen. 2015 Oct;20(9):1150-9. [2]. Sridhar R, et, al. Styryl Quinazolinones as Potential Inducers of Myeloid Differentiation via Upregulation of C/EBPα. Molecules. 2018 Aug 3;23(8):1938.