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Metaxalone-d6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Metaxalone-d6图片
CAS NO:1189944-95-3
包装:1mg
市场价:3311元

产品介绍
An internal standard for the quantification of metaxalone
Cas No.1189944-95-3
别名AHR438-d6; NSC170959-d6
Canonical SMILES[2H]C([2H])([2H])C1=CC(C([2H])([2H])[2H])=CC(OCC(O2)CNC2=O)=C1
分子式C12H9D6NO3
分子量227.3
溶解度Acetonitrile: Soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Metaxalone-d6is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant.1,2It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cellsin vitrowhen used at concentrations ranging from 1 to 100 µM.2Metaxalone also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-α, IL-6, and prostaglandin E2in RAW 264.7 cells. Formulations containing metaxalone have been used in the treatment of lower back pain.

1.Chou, R., Peterson, K., and Helfand, M.Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: A systematic reviewJ. Pain Symptom Manage.28(2)140-175(2004) 2.Yamaguchi, M., and Levy, R.M.Metaxalone suppresses production of inflammatory cytokines associated with painful conditions in mouse macrophages RAW264.7 cells in vitro: Synergistic effect with β-caryophylleneCurr. Mol. Med.20(8)643-652(2020)