| CAS NO: | 1189944-95-3 |
| 包装: | 1mg |
| 市场价: | 3311元 |
| Cas No. | 1189944-95-3 |
| 别名 | AHR438-d6; NSC170959-d6 |
| Canonical SMILES | [2H]C([2H])([2H])C1=CC(C([2H])([2H])[2H])=CC(OCC(O2)CNC2=O)=C1 |
| 分子式 | C12H9D6NO3 |
| 分子量 | 227.3 |
| 溶解度 | Acetonitrile: Soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Metaxalone-d6is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant.1,2It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cellsin vitrowhen used at concentrations ranging from 1 to 100 µM.2Metaxalone also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-α, IL-6, and prostaglandin E2in RAW 264.7 cells. Formulations containing metaxalone have been used in the treatment of lower back pain. 1.Chou, R., Peterson, K., and Helfand, M.Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: A systematic reviewJ. Pain Symptom Manage.28(2)140-175(2004) 2.Yamaguchi, M., and Levy, R.M.Metaxalone suppresses production of inflammatory cytokines associated with painful conditions in mouse macrophages RAW264.7 cells in vitro: Synergistic effect with β-caryophylleneCurr. Mol. Med.20(8)643-652(2020) |
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