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2',2'-Difluoro-2'-deoxyuridine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
2',2'-Difluoro-2'-deoxyuridine图片
CAS NO:114248-23-6
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
An active metabolite of gemcitabine
Cas No.114248-23-6
别名2'-脱氧-2',2'-二氟尿嘧啶核苷
Canonical SMILESO=C(N(C=C1)[C@H]2C(F)(F)[C@H](O)[C@@H](CO)O2)NC1=O
分子式C9H10F2N2O5
分子量264.2
溶解度DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2',2'-Difluoro-2'-deoxyuridine is an active metabolite of the anticancer nucleoside analog gemcitabine .1It is formed by deamination of gemcitabine by cytidine deaminase in the liver. 2',2'-Difluoro-2'-deoxyuridine is cytotoxic to HepG2 and A549 cancer cells (IC50s = 3.13 and 3.92 µM, respectively). It enhances radiation-induced cell death of ECV304 and NCI H292 cells when used at concentrations ranging from 10 to 100 µM.2

1.Veltkamp, S.A., Pluim, D., van Eijndhoven, M.A.J., et al.New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridineMol. Cancer Ther.7(8)2415-2425(2008) 2.Pauwels, B., Korst, A.E.C., Lambrechts, H.A.J., et al.The radiosensitising effect of difluorodeoxyuridine, a metabolite of gemcitabine, in vitroCancer Chemother. Pharmacol.58(2)219-228(2006)