MC1742

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MC1742

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1776116-74-5

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议

产品介绍

MC1742 是一种有效的 HDAC 抑制剂，对 HDAC1、HDAC2、HDAC3、HDAC6、HDAC8、HDAC10 和 HDAC11 的 IC50 分别为 0.1 μM、0.11 μM、0.02 μM、0.007 μM、0.61 μM、0.04 μM 和 0.1 μM。 MC1742 可以增加乙酰 H3 和乙酰微管蛋白水平并抑制癌症干细胞的生长。 MC1742 可诱导肉瘤 CSC 的生长停滞、细胞凋亡和分化。

Cas No.	1776116-74-5
Canonical SMILES	O=C1N=C(SCCCCC(NO)=O)NC(C(C=C2)=CC=C2C3=CC=CC=C3)=C1
分子式	C₂₁H₂₁N₃O₃S
分子量	395.5
溶解度	DMSO: 100 mM
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	MC1742 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.1, 0.11, 0.02, and 0.61 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively).1 It is selective for class I and class IIb over class IIa HDACs (IC50s = >50 μM for HDAC4, -5, -7, and -9). MC1742 reduces proliferation of HOS, MG-63, RD, A204, SK-ES-1, and A673 sarcoma cancer stem cells (CSCs). It increases levels of acetylated histone H3 and acetylated tubulin and induces apoptosis in MG-63 CSCs when used at a concentration of 2 μM. MC1742 also reactivates HIV-1 in JLAT 10.6 latently infected cells (EC50 = 350 nM).2 \|1. Di Pompo, G., Salerno, M., Rotili, D., et al. Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. J. Med. Chem. 58(9), 4073-4079 (2015).\|2. Heffern, E.F.W., Ramani, R., Marshall, G., et al. Identification of isoform-selective hydroxamic acid derivatives that potently reactivate HIV from latency. J. Virus Erad. 5(2), 84-91 (2019).