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SD 0006
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
SD 0006图片
CAS NO:271576-80-8
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
1mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
SD 0006 (SD-06) 是一种具有口服活性、选择性、ATP 竞争性和有效的 p38α MAP 激酶二芳基吡唑抑制剂，对 p38α 的 IC50 为 110 nM。
Cas No.271576-80-8
别名3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑,SD-06
Canonical SMILESOCC(N1CCC(CC1)C2=NNC(C3=CC=C(C=C3)Cl)=C2C4=NC=NC=C4)=O
分子式C20H20ClN5O2
分子量397.86
溶解度DMSO : ≥ 29 mg/mL (72.89 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38α MAP kinase, with an IC50 of 110 nM for p38α[1][2].

SD 0006 clearly inhibits p38α as shown by the dose-dependent inhibition of phosphorylation of its endogenous Hsp27 substrate[1].

SD 0006 (0-30 mg/kg) may be an effective alternative to steroids and biologics for RA therapy[1].SD0006 (3.75, 7.5 and 15 mg/kg; p.o.; b.i.d.) is highly effective in attenuating SCW-induced inflammation as shown by the dose-dependent inhibition of paw swelling[1].

References:
[1]. Burnette BL, et al. SD0006: a potent, selective and orally available inhibitor of p38 kinase. Pharmacology. 2009;84(1):42-60.
[2]. Walker JK, et al. Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2634-8.