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Dasatinib N-oxide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Dasatinib N-oxide图片
CAS NO:910297-52-8
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
达沙替尼 N-氧化物是达沙替尼的次要代谢物。达沙替尼是一种有效且具有口服活性的双重 Src/Bcr-Abl 抑制剂。
Cas No.910297-52-8
别名达沙替尼N氧化物；达沙替尼杂质
Canonical SMILESOCCN(CCN1C2=CC(NC3=NC=C(C(NC4=C(Cl)C=CC=C4C)=O)S3)=NC(C)=N2)(CC1)=O
分子式C22H26ClN7O3S
分子量504
溶解度Soluble in DMSO
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Dasatinib N-oxide is a major metabolite of the Abl and Src kinase inhibitor dasatinib .1 It is also a potential impurity in commercial preparations of dasatinib.2

|1. Christopher, L.J., Cui, D., Li, W., et al. Biotransformation of [14C]dasatinib: In vitro studies in rat, monkey, and human and disposition after administration to rats and monkeys. Drug Metab. Dispos. 36(7), 1341-1356 (2008).|2. PlachkÁ, K., •vec, F., and NovÁkovÁ, L. Ultra-high performance supercritical fluid chromatography in impurity control: Searching for generic screening approach. Anal. Chim. Acta 1039, 149-161 (2018).