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USP7-IN-8
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
USP7-IN-8图片
CAS NO:2009273-60-1
包装:5mg
市场价:3150元

产品介绍
USP7-IN-8 (example 81) 是一种选择性的泛素特异性蛋白酶 7 (USP7) 抑制剂，在 Ub-Rho110 分析中的 IC50 为 1.4 μM。USP7-IN-8 对 USP47 和 USP5 没有活性。USP7-IN-8 具有抗癌作用。
Cas No.2009273-60-1
分子式C21H21N3O2
分子量347.41
溶解度DMSO : 83.33 mg/mL (239.86 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

USP7-IN-8 (example 81) is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in an Ub-Rho110 assay. USP7-IN-8 shows no activity against USP47 and USP5. USP7-IN-8 has anticancer effects[1].

USP7 or HAUSP (herpesvirus-associated USP) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. USP7 is a eubiquitinase (DUB) that controls cell proliferation by altering the stability of Mdm2, p53, PTEN and FOXO4[1].

[1]. Robert Blake, et al. Usp7 inhibitor compounds and methods of use. US20160272588A1.