| Cas No. | 883046-50-2 |
| 别名 | 8-乙氧基-2-(4-氟苯基)-3-硝基-2H-1-苯并吡喃 |
| 化学名 | 8-ethoxy-2-(4-fluorophenyl)-3-nitro-2H-1-benzopyran |
| Canonical SMILES | FC(C=C1)=CC=C1C2C([N+]([O-])=O)=CC3=CC=CC(OCC)=C3O2 |
| 分子式 | C17H14FNO4 |
| 分子量 | 315.3 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G1 to the S phase. Cell cycle deregulation in many cancers often results from altered cyclin D/CDK activity. S14161 is a small molecule inhibitor of cyclins D1-D3 expression that inhibits phosphoinositide 3-kinase activity and arrests cells at the G0/G1 phase in a dose-dependent manner (concentrations tested from 5-10 μM). S14161 induces apoptosis in myeloma and leukemia cell lines (IC50s 25 μM). In a mouse model of leukemia, S14161 delayed tumor growth by up to 90% compared to controls at a dose of 100 mg/kg/day. |
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