| CAS NO: | 2457357-99-0 |
| 包装: | 1mg |
| 市场价: | 8820元 |
| Cas No. | 2457357-99-0 |
| 分子式 | C9H14FN6O13P3 |
| 分子量 | 526.16 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | FNC-TP is the intracellular active form of FNC. FNC is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV[1]. FNC (0.1-10 nM; 24-240 h) is found mainly to accumulate in these HIV-1 target cells, and the retention of FNC-TP is 2-4 times higher than in other types of cells[1]. FNC (1-6 mg/kg; a single p.o.) could enter rhesus macaque PBMCs and form the active nucleoside triphosphate FNC-TP[1]. [1]. Sun L, et, al. Mechanistic Insight into Antiretroviral Potency of 2’-Deoxy-2’-β-fluoro-4’-azidocytidine (FNC) with a Long-Lasting Effect on HIV-1 Prevention. J Med Chem. 2020 Aug 13;63(15):8554-8566. |
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