N-Desethylamiodarone (hydrochloride) (N-desethylamiodarone hydrochloride) 是胺碘酮的主要活性代谢物。
Cas No. | 96027-74-6 |
别名 | 去乙基胺碘酮,N-desethylamiodarone hydrochloride; LB 33020 hydrochloride |
Canonical SMILES | CCNCCOc1c(I)cc(cc1I)C(=O)c1c(CCCC)oc2ccccc12Cl |
分子式 | C23H25I2NO3•HCl |
分子量 | 653.7 |
溶解度 | DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM. In humans, cytochrome P450 3A is involved in the metabolism of amiodarone. N-Desethylamiodarone is the major, active metabolite of amiodarone. This compound has been used as an analytical reference standard for quantifying amiodarone in plasma samples. |