LG 100268 (LG268) 是一种有效、选择性和口服活性的类视黄醇 X 受体 (RXR) 激动剂，对 RXR-α、RXR-β 和 RXR-γ 的 EC50 值分别为 4 nM、3 nM 和 4 nM。
| Cas No. | 153559-76-3 |
| 别名 | 6-[1-(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)环丙基]-3-吡啶羧酸,LG268 |
| Canonical SMILES | CC1(C)C2=C(C=C(C)C(C3(CC3)C4=NC=C(C(O)=O)C=C4)=C2)C(C)(C)CC1 |
| 分子式 | C24H29NO2 |
| 分子量 | 363.5 |
| 溶解度 | DMF: 20mg/mL,DMSO: 20mg/mL,Ethanol: 1mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | LG 100268 is an agonist of retinoid X receptors (RXRs; Kd = 3 nM). It is selective for RXRs over retinoic acid receptors (RARs; Kd = >10,000 nM). In vitro, LG 100268 (1 µM) induces apoptosis in HL-60 human leukemia cells when used in combination with TTNPB . LG 100268 (100, 300, and 1,000 nM) dose-dependently inhibits COX-2 expression and increases ATP-binding cassette transporter (ABCA1) levels in macrophage-like RAW 264.7 cells. In vivo, it inhibits vinyl carbamate-induced lung tumor growth in mice when administered at a dose of 40 mg/kg. |
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