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Cytochalasin E
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Cytochalasin E图片
CAS NO:36011-19-5
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Cytochalasin E 是一种含有曲霉衍生真菌代谢物的环氧化物，可抑制血管生成和肿瘤生长。 Cytochalasin E 是一种有效的肌动蛋白解聚剂，它结合并覆盖肌动蛋白丝的倒刺末端以防止肌动蛋白伸长。
Cas No.36011-19-5
别名细胞松弛素E
Canonical SMILESO=C(OC12[C@@]([C@H]3[C@](C)(O3)[C@@H](C)[C@@]1([H])[C@H](CC4=CC=CC=C4)NC2=O)([H])/C=C/C[C@]5([H])C)O/C=C/[C@](O)(C)C5=O
分子式C28H33NO7
分子量495.6
溶解度DMF: 11 mg/ml,DMF:PBS (pH7.2) (1:30): 0.03 mg/ml,DMSO: 10 mg/ml,Ethanol: 2 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation[1][2].

Cytochalasin E prominently inhibits the growth of A549 cells in a dose-dependent manner[3].Cytochalasin E could induce the up-regulation of autophagy-related protein (LC3-II) and SQSTM1/p62[3].

References:
[1]. Udagawa T, et al. Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesisand tumor growth. J Pharmacol Exp Ther. 2000 Aug;294(2):421-7.
[2]. Lu QY, et al. Green tea extract modulates actin remodeling via Rho activity in an in vitro multistep carcinogenicmodel. Clin Cancer Res. 2005 Feb 15;11(4):1675-83.
[3]. Takanezawa Y, et al. Variation in the activity of distinct cytochalasins as autophagy inhibitiors in human lung A549 cells. Biochem Biophys Res Commun. 2017 Dec 16;494(3-4):641-647.