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AZD6738(Ceralasertib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZD6738(Ceralasertib)图片
CAS NO:1352226-88-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品名称
AZD-6738, AZD 6738
产品介绍

生物活性

AZD6738是一种有效的ATR激酶抑制剂,对分离的酶的IC50为1 nM,对细胞中ATR激酶依赖性CHK1磷酸化的IC50为74 nM。

靶点信息

ATR
1 nM

化学数据

目录号A15794
作用机制Inhibitor (抑制剂)
M. Wt412.51
FormulaC20H24N6O2S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1352226-88-0
SynonymsAZD-6738, AZD 6738
SMILESC[C@H]1N(C2=NC(C3=C4C(NC=C4)=NC=C3)=NC(C5([S@](=O)(C)=N)CC5)=C2)CCOC1

溶解度

In vitro (25°C)DMSO75 mg/mL (181.81 mM)
WaterInsoluble
EthanolWarmed: 38 mg/mL
In vivo5% DMSO+40% propylene glycol+ddH2O9 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM24.24 mL121.21 mL242.42 mL
0.5 mM4.85 mL24.24 mL48.48 mL
1 mM2.42 mL12.12 mL24.24 mL
5 mM0.48 mL2.42 mL4.85 mL

*The above data is based on the productmolecular weight 412.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.