CAS NO: | 39122-38-8 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
Cas No. | 39122-38-8 |
Canonical SMILES | S=C(C1=NC=CC=C1)NC2=NC=CC=C2 |
分子式 | C11H9N3S |
分子量 | 215.27 |
溶解度 | DMSO : ≥ 125 mg/mL (580.67 mM) |
储存条件 | 4°C, protect from light |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. NSC185058 markedly attenuates autophagic activity[1]. ATG4B[1]Autophagy[1] NSC185058 is an ATG4B antagonist. ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. Inclusion of the ATG4B inhibitor NSC185058 enhances the anti-tumor activity of radiation therapy (RT). NSC185058 decreases glioblastoma (GBM) cell tumorigenicity, and enhances the anti-tumor activity of RT when applied to orthotopic GBM xenograft models[1]. [1]. Huang T, et al. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell. 2017 Dec 11;32(6):840-855.e8. |