| CAS NO: | 358721-70-7 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 358721-70-7 |
| Canonical SMILES | N12C(C(C3=CC=CN=C3)NC4=C2C=CC=C4)=CC=C1 |
| 分子式 | C16H13N3 |
| 分子量 | 247.29 |
| 溶解度 | DMSO : 125 mg/mL (505.48 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM[1]. SIRT6|38 μM (EC50) UBCS039 (75 μM, 48 or 72 hours) induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells[2].UBCS039 leads to autophagosome accumulation in human cancer cells[2].UBCS039 induces autophagy via AMP-activated protein kinase (AMPK) signaling pathway activation[2]. Western Blot Analysis[2] Cell Line: Human H1299 cells. [1]. Led to a strong decrease of cell proliferation in a dose-dependent manner when compared with control or DMSO-treated cells, starting from day 3 of growth (48 h after treatment) in both H1299 and HeLa cell lines. [2]. Sara Iachettini, et al. Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells. Cell Death and Disease (2018) 9:996. |
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