SD 1008 是一种有效的 JAK 抑制剂。 SD 1008 抑制 STAT3、JAK2 和 Src 的酪氨酰磷酸化。 SD 1008 还降低 STAT3 依赖性荧光素酶活性。 SD 1008 通过直接阻断 JAK-STAT3 信号通路增强紫杉醇诱导的卵巢癌细胞凋亡。
| Cas No. | 960201-81-4 |
| 化学名 | (1R,5R,6S,7R)-dimethyl 8-benzyl-2-oxo-8-azabicyclo[3.2.1]oct-3-ene-6,7-dicarboxylate |
| Canonical SMILES | O=C([C@H]1[C@@H]2C(C=C[C@@H](N2CC3=CC=CC=C3)[C@H]1C(OC)=O)=O)OC |
| 分子式 | C18H19NO5 |
| 分子量 | 329.35 |
| 溶解度 | <32.94mg/ml in DMSO |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | JAK2/STAT3 signaling pathway inhibitor. Inhibits activation of STAT3, JAK2 and Src. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3. |
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