RAS inhibitor Abd-7

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RAS inhibitor Abd-7

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2351843-48-4

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议

产品介绍

RAS inhibitor Abd-7 是一种有效的 RAS 结合物 (Kd=51 nM)，是 RAS 效应蛋白相互作用 (RAS-effector protein-protein interaction) 的抑制剂。RAS inhibitor Abd-7 与细胞内 RAS 相互作用，阻止 RAS-效应因子相互作用，抑制内源性 RAS 依赖性信号传导。RAS inhibitor Abd-7 破坏了突变体 KRAS 蛋白与 PI3K、CRAF 和 RALGDS 以及 NRAS Q61H 和 HRAS G12V 的蛋白-蛋白相互作用。

Cas No.	2351843-48-4
分子式	C₂₃H₂₅N₃O₃
分子量	391.46
溶解度	DMSO : 125 mg/mL (319.32 mM; Need ultrasonic)\|Water :< 0.1 mg/mL (insoluble)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	RAS inhibitor Abd-7, a potent RAS-binding compound (Kd=51 nM), is a RAS-effector protein-protein interaction (PPI) inhibitor. RAS inhibitor Abd-7 interacts with RAS inside the cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signaling. RAS inhibitor Abd-7 impairs the PPI of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRAS Q61H and HRAS G12V[1]. RAS inhibitor Abd-7 (0-20 μM; 24-48 hours) is a cell-potent inhibitor affecting the viability of cancer cell lines in a single digit to low micromolar range[1]. [1]. Quevedo CE, et al. Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment. Nat Commun. 2018;9(1):3169. Published 2018 Aug 9.