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BIBP3226
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BIBP3226图片
CAS NO:159013-54-4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
BIBP3226 是一种有效的选择性神经肽 Y Y1 (NPY Y1) 和神经肽 FF (NPFF) 受体拮抗剂,对 rNPY Y1、hNPFF2 和 rNPFF 的 Kis 分别为 1.1、79 和 108 nM。
Cas No.159013-54-4
Canonical SMILESOC(C=C1)=CC=C1CNC([C@@H](CCCNC(N)=N)NC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)=O
分子式C27H31N5O3
分子量473.6
溶解度DMSO: soluble,Ethanol: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

BIBP3226 is a nonpeptide antagonist of neuropeptide Y (NPY) receptor Y1(Ki= 1.1 nM).1It is selective for Y1over Y2, Y4, and Y5receptors (Kis = >1,000 nM for all). It also binds to neuropeptide FF receptor 1 (NPFF1) and NPFF2 (Kis = 108 and 79 nM, respectively) and reverses NPFF-induced inhibition of forskolin-induced cAMP accumulation in CHO cells expressing human NPFF2 in a concentration-dependent manner.1BIBP3226 inhibits NPY-induced increases in perfusion pressure in isolated rat kidney but not the NPY-induced twitch response in isolated rat vas deferens (IC50s = 26 and >10,000 nM, respectively).2BIBP3226 inhibits NPY-induced increases in blood pressure in pithed rats (ED50= 0.11 mg/kg).2It also inhibits NPFF-induced hypothermia in mice when administered intracerebroventricularly (i.c.v.) at a dose of 5 nmol.3

1.Mollereau, C., GouardÈres, C., Dumont, Y., et al.Agonist and antagonist activities on human NPFF2 receptors of the NPY ligands GR231118 and BIBP3226Br. J. Pharmacol.133(1)1-4(2001) 2.Rudolf, K., Eberlein, W., Engel, W., et al.The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP3226Eur. J. Pharmacol.271(2-3)R11-R13(1994) 3.Fang, Q., Guo, J., He, F., et al.In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor antagonistPeptides27(9)2207-2213(2006)