您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Vardenafil-d5
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Vardenafil-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vardenafil-d5图片
CAS NO:1189685-70-8
包装与价格:
包装价格(元)
500 μg电议
1mg电议

产品介绍
An internal standard for the quantification of vardenafil
Cas No.1189685-70-8
别名伐地那非-d5杂质17
Canonical SMILESCC(N=C1CCC)=C2N1NC(C3=CC(S(=O)(N4CCN(C([2H])([2H])C([2H])([2H])[2H])CC4)=O)=CC=C3OCC)=NC2=O
分子式C23H27D5N6O4S
分子量493.6
溶解度Water: 0.11 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Vardenafil-d5is intended for use as an internal standard for the quantification of vardenafil by GC- or LC-MS. Vardenafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50s = 0.2-1.2 nM) and PDE6 (IC50= 2 nM).1,2,3It is selective for PDE5 and PDE6 over PDE1 and PDE11 (IC50s = 230 and 130 nM, respectively). Vardenafil (4 mg/kg per day for three weeks) improves erectile function in a rat model of acute arteriogenic erectile dysfunction by increasing intracavernous pressure and mean arterial pressure, and this effect persists for at least two weeks following the end of treatment.4Chronic vardenafil administration at a dose of 2 mg/kg for five weeks to subordinate mice reduces the latency to mount and increases the frequency of mounting behavior.5Formulations containing vardenafil have been used in the treatment of erectile dysfunction.

1.Card, G.L., England, B.P., Suzuki, Y., et al.Structural basis for the activity of drugs that inhibit phosphodiesterasesStructure12(12)2233-2247(2004) 2.Boyle, C.D., Xu, R., Asberom, T., et al.Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male EDBioorg. Med. Chem. Lett.15(9)2365-2369(2005) 3.Smith, W.B., II, McCaslin, I.R., Gokce, A., et al.PDE5 inhibitors: Considerations for preference and long-term adherenceInt. J. Clin. Pract.67(8)768-780(2013) 4.Hotta, Y., Ohno, R., Kataoka, T., et al.Effects of chronic vardenafil treatment persist after end of treatment in rats with acute arteriogenic erectile dysfunctionJ. Sex Med.9(7)1782-1788(2012) 5.Dadomo, H., Parmigiani, S., Nicolini, Y., et al.Repeated and chronic administration of Vardenafil or Sildenafil differentially affects emotional and socio-sexual behavior in miceBehav. Brain Res.253103-112(2013)