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1,2,3,4-Tetrahydrostaurosporine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
1,2,3,4-Tetrahydrostaurosporine图片
CAS NO:220038-19-7
包装:1mg
市场价:7031元

产品介绍
A mutant EGFR inhibitor
Cas No.220038-19-7
Canonical SMILES[H][C@]12N(C3=C4C5=C(CNC5=O)C6=C3N([C@](O2)(C)[C@H](OC)[C@H](NC)C1)C7=CC=CC=C76)C8=C4CCCC8
分子式C28H30N4O3
分子量470.6
溶解度Acetone: slightly soluble,DMSO: slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

1,2,3,4-Tetrahydrostaurosporine is a derivative of staurosporine and an inhibitor of mutant EGFR (IC50 = 74 nM for EGFRT790M).1 It is selective for EGFRT790M over wild-type EGFR (IC50 = 390 nM). It also binds to Janus kinase 3 (JAK3).2

|1. Song, X., Liu, X., and Ding, X. Staurosporine scaffold-based rational discovery of the wild-type sparing reversible inhibitors of EGFR T790M gatekeeper mutant in lung cancer with analog-sensitive kinase technology. J. Mol. Recognit. 30(4), (2017).|2. Boggon, T.J., Li, Y., Manley, P.W., et al. Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog. Blood 106(3), 996-1002 (2005).