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Tenuazonic Acid(copper salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tenuazonic Acid(copper salt)图片
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
别名AAC-toxin
化学名3-acetyl-1,5-dihydro-4-hydroxy-5S-[(1S)-1-methylpropyl]-2H-pyrrol-2-one, monocopper salt
Canonical SMILESO=C1C(C(C)=O)=C(O)[C@@]([C@H](CC)C)([H])N1.[Cu+2]
分子式C10H15NO3o Cu
分子量260.8
溶解度20mg/ml in ethanol & DMSO; 30mg/m; in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tenuazonic acid is one of the major Alternaria mycotoxins commonly found as a natural contaminant in food (LD50 = 548 μg/egg in the chicken embryo toxicity assay).[1] Tenuazonic acid contamination has been linked to esophageal cancer in human populations at risk of high exposure. Mice fed 100 mg/kg/day tenuazonic acid orally for 10 months developed precancerous lesions on the esophageal mucosa.[2] Microscopic analysis of mucosal epithelial cells from these tenuazonic acid-treated animals reveal pyknosis and marked pleomorphisms in the nuclei, chromatin granulation and increased chromatin mass, irregularities in nuclear contours, and vacuolization in nucleoplasms.[2]

Reference:
1. Griffin, G.F., and Chu, F.S. Toxicity of the Alternaria metabolites alternariol, alternariol methyl ether, altenuene, and tenuazonic acid in the chicken embryo assay. Applied and Environmental Microbiology 46(6), 1420-1422 (1983).
2. Yekeler, H., Bitmis, K., Ozcelik, N., et al. Analysis of toxic effects of Alternaria toxins on esophagus of mice by light and electron microscopy. Toxicologic Pathology 29, 492-497 (2001).