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Prochloraz
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Prochloraz图片
CAS NO:67747-09-5
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
250mg电议

产品介绍
Prochloraz 是一种咪唑类抗真菌剂,通过抑制羊毛甾醇的细胞色素 P450 依赖性 14α-去甲基化来抑制麦角甾醇的生物合成,从而导致真菌细胞膜的破坏和细胞死亡。
Cas No.67747-09-5
别名咪鲜胺; BTS 40542
Canonical SMILESClC1=C(OCCN(CCC)C(N2C=NC=C2)=O)C(Cl)=CC(Cl)=C1
分子式C15H16Cl3N3O2
分子量376.7
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
储存条件Store at 0-6°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Prochloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. It inhibits human placenta microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an antagonist of the estrogen receptor (ER) and androgen receptor (AR) (IC50s = 25 and 4 μM, respectively) as well as activates the aryl hydrocarbon receptor (AhR; EC50 = 1 μM). In vivo, prochloraz (250 mg/kg) reduces the weight of seminal vesicles in intact male rats and of seminal vesicles, ventral prostate, and bulbourethral glands in castrated testosterone-treated male rats. It also reduces testosterone levels and increases progesterone levels in male rat pups following administration of a 30 mg/kg per day dose to pregnant females during gestation. Formulations containing prochloraz have been used to control fungal growth in mushroom cultivation.