p,p'-DDE (4,4'-DDE) 是持久性二氯二苯三氯乙烷 (DDT) 的主要代谢物，是一种有效的雄激素受体拮抗剂，IC50 为 5 μM，Ki 为 3.5 μM。
| Cas No. | 72-55-9 |
| 别名 | 2，2-双（4-氯苯基）-1，1-二氯乙烯,4,4'-DDE; p,p'-Dichlorodiphenyldichloroethylene |
| Canonical SMILES | ClC1=CC=C(/C(C2=CC=C(Cl)C=C2)=C(Cl)\Cl)C=C1 |
| 分子式 | C14H8Cl4 |
| 分子量 | 318 |
| 溶解度 | Chloroform: Slightly Soluble |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | p,p'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT. It accumulates in smallmouth buffalo, channel catfish, and largemouth bass as well as sediment in the Huntsville Spring Branch-Indian Creek tributary system surrounding a DDT manufacturing plant where it is considered a persistent organic pollutant (POP). p,p'-DDE inhibits estrogen binding to rainbow trout estrogen receptors (rtERs) with an IC50 value of 8 µM. It induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles. p,p'-DDE (50-100 µM) also decreases ATP levels, the proportion of sperm with high mitochondrial membrane potential, and motility of human sperm in vitro. |
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