您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > JMV3002
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
JMV3002
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JMV3002图片
CAS NO:925239-03-8
包装与价格:
包装价格(元)
100μg电议
500μg电议
1mg电议
5mg电议

产品介绍
Cas No.925239-03-8
Canonical SMILESCOc1ccc(Cn2c(CCc3ccccc3)nnc2C(NC(=O)c2ccccn2)Cc2c[nH]c3ccccc23)c(OC)c1
分子式C35H34N6O3
分子量586.7
溶解度DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. JMV3002 is a potent ghrelin receptor antagonist with an IC50 value of 1.1 nM in vitro. At 80 µg/kg, JMV3002 inhibits hexarelin-stimulated food intake by as much as 98% in rats. JMV3002 alone does not elicit growth hormone release nor does it inhibit hexarelin-stimulated growth hormone secretion when tested in infant rats at a dose of 160 µg/kg.