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M04
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
M04图片
CAS NO:875158-73-9
包装与价格:
包装价格(元)
500 µg电议
1mg电议

产品介绍
A STING agonist
Cas No.875158-73-9
Canonical SMILESO=S(C1=CC=C(C)C=C1)(C2=C(N(C)C)SC(S(=O)(C3CCCCC3)=O)=N2)=O
分子式C18H24N2O4S3
分子量428.6
溶解度Chloroform: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

M04 is an agonist of stimulator of interferon genes (STING).1It induces IFN reporter gene expression in HEK293T cells expressing wild-type human STING but not in HEK293T cells expressing the R71H-G230A-R293Q (HAQ) human STING variant nor in mouse RAW 264.7 cells, indicating allelic- and species-dependent activities, at 75 µM. M04 induces the production of TNF-α, IL-10, IL-1β, and IL-12p70 in human peripheral blood mononuclear cells (PBMCs). It increases the percentage of isolated human monocyte-derived dendritic cells expressing the MHC class II cell surface receptor HLA-DR and the co-stimulatory molecules CD40, CD80, and CD86, as well as increases T cell cross-priming of the same cells in anex vivoassay, when used at a concentration of 50 µM.

1.Abraham, J., Botto, S., Mizuno, N., et al.Characterization of a novel compound that stimulates STING-mediated innate immune activity in an allele-specific mannerFront. Immunol.111430(2020)