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Trifluoperazine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Trifluoperazine图片
CAS NO:117-89-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Trifluoperazine 是一种抗精神病药物,通过阻断中枢多巴胺受体 (dopamine receptors) 起作用。Trifluoperazine 是一种有效的 α1-adrenergic 受体拮抗剂。Trifluoperazine 是一种有效的 NUPR1 抑制剂,具有抗癌活性。Trifluoperazine是一种钙调蛋白 (calmodulin) 抑制剂,还可抑制 P-糖蛋白 (P-glycoprotein),可用于精神分裂症的研究。Trifluoperazine 是流感病毒 (influenza virus) 形态发生的可逆抑制剂。
Cas No.117-89-5
别名三氟拉嗪
分子式C21H24F3N3S
分子量407.5
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Trifluoperazine, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine is a potent α1-adrenergic receptor antagonist. Trifluoperazine is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine can be used for the research of schizophrenia. Trifluoperazine acts as a reversible inhibitor of influenza virus morphogenesis[1][2][3][4][5].

Trifluoperazine is a long-established, widely used ’conventional’ antipsychotic agent. Trifluoperazine has been an extensively studied drug molecule that has been used as a calmodulin inhibitor[3][4].Trifluoperazine acts as a reversible inhibitor of influenza virus morphogenesis, but not budding, by disturbing cellular CaM and/or CaM-dependent functions[5].

[1]. Huerta-Bahena J, Villalobos-Molina R, GarcÍa-SÁinz JA. Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects. Mol Pharmacol. 1983;23(1):67-70.
[2]. Santofimia-CastaÑo P, et al. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 2019;129(6):2500-2513. Published 2019 Mar 28.
[3]. Marques LO, Lima MS, Soares BG. Trifluoperazine for schizophrenia. Cochrane Database Syst Rev. 2004;2004(1):CD003545.
[4]. Howland RH. Trifluoperazine: A Sprightly Old Drug. J Psychosoc Nurs Ment Health Serv. 2016;54(1):20-22.
[5]. Ochiai H, et al. Influence of trifluoperazine on the late stage of influenza virus infection in MDCK cells. Antiviral Res. 1991;15(2):149-160.