NS 383 是一种有效且独特的选择性大鼠 ASIC 抑制剂,含有 1a 和/或 3 个亚基。
Cas No. | 309711-59-9 |
Canonical SMILES | CCN1CCC2=C(C3=C(/C(C(N3)=O)=N\O)C=C2C4=CC=CC=C4)C1 |
分子式 | C19H19N3O2 |
分子量 | 321.37 |
溶解度 | DMSO|1.61|5| |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | ASIC blocker (IC50 values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats. |