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1,2,3,4-Tetrahydro-β-carboline
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
1,2,3,4-Tetrahydro-β-carboline图片
CAS NO:16502-01-5
包装与价格：
包装价格(元)
1 g电议
5 g电议

产品介绍
A serotonin reuptake inhibitor and metabolite of tryptamine
Cas No.16502-01-5
别名1,2,3,4-四氢-9H-吡啶[3,4-B]并吲哚
Canonical SMILESC1(C=CC=C2)=C2C(CCNC3)=C3N1
分子式C11H12N2
分子量172.2
溶解度DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.33 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

1,2,3,4-Tetrahydro-β-carboline is a serotonin reuptake inhibitor (IC50= 7.4 µM in rat brain homogenates) and metabolite of tryptamine .1In vivo, 1,2,3,4-tetrahydro-β-carboline (20 and 40 µg/animal, i.c.v.) reduces serotonin levels in rat forebrain. It induces serotonin-mediated hyperactivity syndrome (HHS) in rats (ED50= 48 mg/kg).21,2,3,4-Tetrahydro-β-carboline (6.25-75 mg/kg) also reduces acetic acid-induced writhing in rats.3

1.Rommelspacher, H., Bade, P., Coper, H., et al.Inhibition of the reuptake of serotonin by tryptolineNaunyn Schmiedebergs Arch. Pharmacol.292(1)93-95(1976) 2.Pannier, L., and Rommelspacher, H.Actions of tetrahydronorharmane (tetrahydro-β-carboline) on 5-hydroxytryptamine and dopamine mediated mechanismsNeuropharmacology20(1)1-8(1981) 3.Rommelspacher, H., Kauffmann, H., Cohnitz, C.H., et al.Pharmacological properties of tetrahydronorharmane (tryptoline)Naunyn Schmiedebergs Arch. Pharmacol.298(2)83-91(1977)