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ACP-196(Acalabrutinib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ACP-196(Acalabrutinib)图片
CAS NO:1420477-60-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品名称
Acalabrutinib, ACP196, ACP 196
产品介绍

生物活性

ACP-196是Bruton酪氨酸激酶(BTK)抑制剂,具有潜在的抗肿瘤活性。它抑制BTK的活性并阻止B细胞抗原受体(BCR)信号传导途径的激活。

靶点信息

BTK
3nM

化学数据

目录号A15824
作用机制Inhibitor (抑制剂)
M. Wt465.52
FormulaC26H23N7O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1420477-60-6
SynonymsAcalabrutinib, ACP196, ACP 196
SMILESCC#CC(=O)N1CCCC1C2=NC(=C3N2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=CC=CC=N5

溶解度

In vitro (25°C)DMSO80 mg/mL (171.85 mM)
WaterInsoluble
Ethanol80 mg/mL (171.85 mM)
In vivo2% DMSO+30% PEG 300+2% Tween 80+ddH2O5 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM21.48 mL107.41 mL214.81 mL
0.5 mM4.3 mL21.48 mL42.96 mL
1 mM2.15 mL10.74 mL21.48 mL
5 mM0.43 mL2.15 mL4.3 mL

*The above data is based on the productmolecular weight 465.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.