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NT1-O12B
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NT1-O12B图片
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
NT1-O12B 是一种内源性化学物质,也是一种神经递质衍生的类脂质体 (NT-lipidoid),是几种血脑屏障 (BBB) 非渗透性物质增强脑内转运的有效载体。将 NT1-O12B 掺杂到 BBB 非渗透性脂质纳米粒 (LNPs) 中,可以使 LNPs 具有穿过 BBB 的能力。NT 类脂质体不仅有利于 BBB 的跨膜转运,而且可以将其转运到神经细胞中进行功能基因沉默或基因重组。
分子式C36H60N2O4S4
分子量713.13
溶解度DMSO : 200 mg/mL (280.45 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB)-impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination[1].

NT1-O12B indicates a lipidoid containing a tryptamine head group and a hydrophobic tail group containing 12 carbon atoms[1].

It encapsulates AmB in pure NT1-lipidoids (namely NT1-O12B, NT1-O14B, NT1-O16B, and NT1-O18B) using a procedure similar to the DiR encapsulation. NT1-O12B is the dopant for enhanced brain delivery because it shows the highest DiR fluorescence intensity among all NT-lipidoids. Doping NT1-O12B to the BBB-impermeable lipidoid PBA-Q76-O16B resulted in an AmB formulation that could cross BBB. Using this approach, the AmB concentration in the brain tissue reached as high as 300 ng/g (AmB/tissue) with a delivery efficiency of about 0.135% of injected dose after 24 hours of intravenous injection with AmB (5 mg/kg)[1].

[1]. Ma F, et al. Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection. Sci Adv. 2020;6(30):eabb4429. Published 2020 Jul 24.