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IYPTNGYTR acetate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
IYPTNGYTR acetate图片
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
IYPTNGYTR acetate，一种脱酰胺敏感的特征肽，是曲妥珠单抗 (Trastuzumab) 的脱酰胺产物。 IYPTNGYTR acetate 可用于监测体内曲妥珠单抗的代谢。
分子式C51H77N13O17
分子量1144.23
溶解度Water : 125 mg/mL (109.24 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IYPTNGYTR acetate, a deamidation-sensitive signature peptide, is a deamidation product of Trastuzumab. IYPTNGYTR acetate can be used to monitor in vivo Trastuzumab metabolism[1].

IYPTNGYTR is deamidated at pH 7.5 and above, with a higher deamidation rate when the pH increases[1].

[1]. Bults P, et, al. LC-MS/MS-Based Monitoring of In Vivo Protein Biotransformation: Quantitative Determination of Trastuzumab and Its Deamidation Products in Human Plasma. Anal Chem. 2016 Feb 2;88(3):1871-7.