| CAS NO: | 103-85-5 |
| 包装 | 价格(元) |
| 25 g | 电议 |
| 50 g | 电议 |
| 100 g | 电议 |
| 250 g | 电议 |
| Cas No. | 103-85-5 |
| 别名 | 苯基硫脲 |
| Canonical SMILES | NC(NC1=CC=CC=C1)=S |
| 分子式 | C7H8N2S |
| 分子量 | 152.2 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | N-Phenylthiourea is a tyrosinase inhibitor (Ki= 0.21 μM in an enzyme assay using L-DOPA as a substrate) and building block.1,2It increases the susceptibility of SK-MEL-188 melanoma cells in melanogenesis-inducing conditions to γ-radiation-induced cytotoxicity when used at a concentration of 0.01 μM.3N-Phenylthiourea has been used as a precursor in the synthesis of compounds with antibacterial and antifungal activities.2It has also been used as a genetic marker for taste because only some people detect it as a bitter taste.4 1.Ryanzanova, A.D., Alekseev, A.A., and Slepneva, I.A.The phenylthiourea is a competitive inhibitor of the enzymatic oxidation of DOPA by phenoloxidaseJ. Enzyme Inhib. Med. Chem.27(1)78-83(2012) 2.Soni, B., Bhandari, A.A., Ranawat, M.S., et al.Synthesis and antimicrobial activity of 2-substituted benzothiazole containing azomethine linkagePharmacophore2(1)24-33(2011) 3.Bro?yna, A.A., VanMiddlesworth, L., and Slominski, A.T.Inhibition of melanogenesis as a radiation sensitizer for melanoma therapyInt. J. Cancer123(6)1448-1456(2008) 4.Drewnowski, A., and Rock, C.L.The influence of genetic taste markers on food acceptanceAm. J. Clin. Nutr.62(3)506-511(1995) |
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