生物活性
BML-284 (Wnt agonist 1)是细胞可渗透的Wnt信号传导活化剂。它诱导β-catenin和TCF依赖性转录活性，EC50值为0.7 uM。
化学数据
| 目录号 | A15851 |
| 作用机制 | Agonist (激动剂) |
| M. Wt | 350.37 |
| Formula | C19H18N4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 853220-52-7 |
| Synonyms | BML-284, BML284, BML 284 |
| SMILES | COC1=CC=CC(C2=CC(NCC3=CC=C(OCO4)C4=C3)=NC(N)=N2)=C1 |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 28.54 mL | 142.71 mL | 285.41 mL |
| 0.5 mM | 5.71 mL | 28.54 mL | 57.08 mL |
| 1 mM | 2.85 mL | 14.27 mL | 28.54 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.71 mL |
*The above data is based on the productmolecular weight 350.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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