CAS NO: | 70253-62-2 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
Cas No. | 70253-62-2 |
别名 | 新螺旋霉素I |
Canonical SMILES | O=CC[C@@H](C[C@H]([C@H](/C=C/C=C/C[C@H](OC(C[C@H]([C@@H]1OC)O)=O)C)O[C@@H]2O[C@@H]([C@H](CC2)N(C)C)C)C)[C@@H]1O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)C)O)N(C)C)OO=CC[C@@H](C[C@H]([C@H](/C=C/C=C/C[C@H](OC(C[C@H]([C@@H]1OC)O)=O)C)O[C@@H]2O[C@@H]([C@H](CC2)N(C)C)C)C)[C@@H]1O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)C)O)N(C)C)O |
分子式 | C36H62N2O11 |
分子量 | 698.9 |
溶解度 | DMSO: soluble |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Neospiramycin I is a macrolide antibiotic and derivative of spiramycin I.1It is active against the macrolide-sensitive KB210, but not the macrolide-resistant KB224, strain ofS. aureus(MICs = 3.12 and >100 µg/ml, respectively), as well asB. cereus,B. subtilis,M. luteus,E. coli, andK. pneumoniae(MICs = 1.56, 3.12, 3.12, 0.2, 50, and 12.5 µg/ml, respectively). Neospiramycin I binds toE. coliribosomes with an IC50value of 1.2 µM. It protects against mortality in a mouse model ofS. pneumoniaetype III infection (ED50= 399.8 mg/kg).2 1.Sano, H., Inoue, M., and ?mura, S.Chemical modification of spiramycins. II. Synthesis and antimicrobial activity of 4’-deoxy derivatives of neospiramycin I and their 12-(Z)-isomersJ. Antibiot. (Tokyo)37(7)738-749(1984) 2.Sano, H., Inoue, M., Yamashita, K., et al.Chemical modification of spiramycins. I. Synthesis of the acetal derivatives of neospiramycin IJ. Antibiot. (Tokyo)36(10)1336-1344(1983) |