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Tebipenem(hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tebipenem(hydrate)图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1 g电议

产品介绍
A carbenapenem antibiotic
Canonical SMILESOC(C1=C(SC2CN(C3=NCCS3)C2)[C@H](C)[C@@]([C@]4([C@H](O)C)[H])([H])N1C4=O)=O.OOC(C1=C(SC2CN(C3=NCCS3)C2)[C@H](C)[C@@]([C@]4([C@H](O)C)[H])([H])N1C4=O)=O.O
分子式C16H21N3O4S2·XH2O
分子量383.5
溶解度DMSO: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tebipenem is a carbenapenem antibiotic.1,2It is active against a panel of clinical isolates from a variety of bacterial species (MIC50s = ≤0.0039-8 µg/ml), including methicillin-resistant strains ofS. aureusandS. epidermidisand penicillin-resistantS. pneumoniae.1Tebipenem inhibits β-lactamase in a concentration-dependent manner.2It decreases the number of colony forming units (CFUs) in the lungs in a mouse model of penicillin-resistantS. pneumoniaeinfection when administered at doses ranging from 0.32 to 3.2 mg/kg.1

1.Fujimoto, K., Takemoto, K., Hatano, K., et al.Novel carbapenem antibiotics for parenteral and oral applications: In vitro and in vivo activities of 2-aryl carbapenems and their pharmacokinetics in laboratory animalsAntimicrob. Agents Chemother.57(2)697-707(2013) 2.Hazra, S., Xu, H., and Blanchard, J.S.Tebipenem, a new carbapenem antibiotic, is a slow substrate that inhibits the β-lactamase from Mycobacterium tuberculosisBiochemistry53(22)3671-3678(2014)