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Sekikaic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sekikaic Acid图片
CAS NO:607-11-4
包装:1mg
市场价:2858元

产品介绍
A lichen metabolite with diverse biological activities
Cas No.607-11-4
Canonical SMILESCOC1=CC(CCC)=C(C(OC2=C(OC)C=C(CCC)C(C(O)=O)=C2O)=O)C(O)=C1
分子式C22H26O8
分子量418.4
溶解度DMSO: soluble,Ethanol: soluble,Methanol: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Sekikaic acid is a phenolic lichen metabolite that has been found inH. obscurataand has diverse biological activities.1,2,3It scavenges superoxide and DPPH radicals in cell-free assays when used at a concentration of 0.5 µM.1Sekikaic acid is active against the rg recombinant strain of respiratory syncytial virus (RSV; IC50= 5.69 µg/ml).2It inhibits the protein-protein interaction between mixed lineage leukemia 1 (MLL1) and the GACKIX domain of CREB-binding protein (CBP; IC50= 34 µM).3

1.Thadhani, V.M., Choudhary, M.I., Ali, S., et al.Antioxidant activity of some lichen metabolitesNat. Prod. Res.25(19)1827-1837(2011) 2.Lai, D., Odimegwu, D.C., Esimone, C., et al.Phenolic compounds with in vitro activity against respiratory syncytial virus from the Nigerian lichen Ramalina farinaceaPlanta Med.79(15)1440-1446(2013) 3.Majmudar, C.Y., HØjfeldt, J.W., Arevang, C.J., et al.Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300Angew. Chem. Int. Ed. Engl.51(45)11258-11262(2012)