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Sulfosuccinimidyl oleate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Sulfosuccinimidyl oleate图片
CAS NO:135661-44-8
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍

Sulfosuccinimidyloleate是一种长链脂肪酸，抑制脂肪酸向细胞转运。Sulfosuccinimidyloleate结合小胶质细胞表面上的CD36受体。具有抗炎作用。

Cas No.135661-44-8
别名Sulfo-N-succinimidyl oleate
Canonical SMILESO=S(C(C1)C(N(OC(CCCCCCC/C=C\CCCCCCCC)=O)C1=O)=O)(O)=O
分子式C22H37NO7S
分子量459.6
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Sulfosuccinimidyl oleate is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect[1].

Sulfosuccinimidyl oleate (20 μM and 50 μM, 24 hours) alone does not alter the cellular viability. Exposure to 100 ng/ml LPS+5 ng/mL IFNγ modestly, yet significantly reduces the viability of the BV2 cells. Co-treatment with Sulfosuccinimidyl oleate prevents the LPS+IFNγ-induced reduction in the cell viability[1]. Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours)[1].|| Cell Viability Assay[1]||Cell Line:|BV2 cells|Concentration:|20 μM and 50 μM|Incubation Time:|24 hours|Result:|Did not alter the viability of BV2 cells alone. Exposure of BV2 cells to 100 ng/mL LPS and 5 ng/mL IFNγ significantly reduced the viability of BV2 cells while simultaneous treatment with Sulfosuccinimidyl oleate prevented it.|| Western Blot Analysis[1]||Cell Line:|BV2 cells|Concentration:|50 μM |Incubation Time:|24 hours|Result:|Drastically increased the levels of NOS2, COX-2, and P-p38/T-p38.

Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls in male BALB/cABom mice with pMCAo model. In addition, Sulfosuccinimidyl oleate at 50 mg/kg is suitable to see a beneficial effect after stroke[1].|| Animal Model:|4-month-old male BALB/cABom mice with pMCAo model[1]|Dosage:|50 mg/kg|Administration:|Administered once by single oral gavage|Result:|Reduced brain damage following ischemia. Attenuated infarct size.

[1]. Dhungana H, et al. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. J Neuroinflammation. 2017 Dec 4;14(1):237.