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AR7
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AR7图片
CAS NO:80306-38-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
AR7 是一种非典型的 RARA/RARα(视黄酸受体,α)拮抗剂。
Cas No.80306-38-3
Canonical SMILESCC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1
分子式C15H12ClNO
分子量257.71
溶解度DMSO : 25 mg/mL (97.01 mM);Water :< 0.1 mg/mL (insoluble)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

AR7 is a retinoic acid receptor α (RARα) antagonist.

Chaperone-mediated autophagy (CMA) contributes to cellular quality control and the cellular response to stress through the selective degradation of cytosolic proteins in lysosomes. Decrease in CMA activity occurs in aging and in age-related disorders. Signaling through the retinoic acid receptor alpha (RARα) inhibits CMA. AR7, an RARα antagonist, significantly activates CMA activity in mouse fibroblasts. A marked increase in CMA-activating potency is found when AR7 and GR1 are combined, supporting their cooperative effect. Treatment with the transcriptional repressor Actinomycin D partially reduces the stimulatory effect of AR7 on CMA, consistent with transcriptional changes contributing to the upregulation of CMA [1].

References:
[1]. Anguiano J, et al. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Nat Chem Biol. 2013 Jun;9(6):374-82.