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Z62954982
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Z62954982图片
CAS NO:1090893-12-1
包装与价格:
包装价格(元)
1mg (99.87 mM * 24.1 μL in DMSO)电议
5mg (99.87 mM * 120.5 μL in DMSO)电议

产品介绍
Z62954982 (ZINC08010136) 是一种强效的、选择性的、细胞渗透性强的 Rac1 (IC50=12 μM) 抑制剂,比 NSC23766 (IC50=50 μM) 有效性强 4 倍。Z62954982 干扰 Rac1/Tiam1 复合物,降低活性 Rac1 (GTP 结合的 Rac1) 的细胞质水平,而不影响其他 Rho GTPases (如,Cdc42 或 RhoA) 的活性。
Cas No.1090893-12-1
别名ZINC08010136
Canonical SMILESO=C(NC1=CC=C(C)C(S(=O)(N)=O)=C1)C2=CC=CC(OCC3=C(C)ON=C3C)=C2
分子式C20H21N3O5S
分子量415.46
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Z62954982 (ZINC08010136) is a potent, selective and cell-permeable Rac1 (IC50=12 μM) inhibitor that is 4 times more effective than NSC23766 (IC50=50 μM). Z62954982 disrupts the Rac1/Tiam1 complex and decreases cytoplasmic levels of active Rac1 (GTP-bound Rac1), without affecting the activity of other Rho GTPases (such as Cdc42 or RhoA)[1][2].

[1]. Nicola Ferri,et al. Virtual Screening Approach for the Identification of New Rac1 Inhibitors. J Med Chem. 2009 Jul 23;52(14):4087-90. [2]. Xun E Zhang, et al. Activation of RhoA, but Not Rac1, Mediates Early Stages of S1P-Induced Endothelial Barrier Enhancement. PLoS One. 2016 May 17;11(5):e0155490. [3]. Min Yu, et al. Lack of BCR and Abr Promotes Hypoxia-Induced Pulmonary Hypertension in Mice. PLoS One