5'-deoxy-5-Fluorocytidine is an intermediate metabolite of the DNA synthesis inhibitor capecitabine.
| Cas No. | 66335-38-4 |
| 别名 | 5'-脱氧-5-氟胞苷 |
| Canonical SMILES | C[C@H]1O[C@@H](N2C(N=C(N)C(F)=C2)=O)[C@H](O)[C@@H]1O |
| 分子式 | C9H12FN3O4 |
| 分子量 | 245.2 |
| 溶解度 | DMF: 10 mg/ml,DMSO: 20 mg/ml,PBS (pH 7.2): 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 5'-deoxy-5-Fluorocytidine is an intermediate metabolite of the DNA synthesis inhibitor capecitabine . Capecitabine is converted by carboxylesterase to 5'-deoxy-5-fluorocytidine in the liver, then by cytidine deaminase to 5'-deoxy-5-fluorouridine in the liver and tumor tissues, and finally, by thymidine phosphorylase to 5-fluorouracil in tumors. The cytotoxicity of this intermediate occurs only after conversion to 5-fluorouracil. |
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