δ12-Prostaglandin J2 (δ12-PGJ2) 是一种环戊烯酮前列腺素 (PG)，对各种肿瘤细胞的生长具有抗增殖作用。 δ12-Prostaglandin J2 是前列腺素 D2 的天然脱水产物，能够通过半胱天冬酶激活诱导 HeLa 细胞凋亡。
| Cas No. | 87893-54-7 |
| 别名 | Δ12-PGJ2 |
| Canonical SMILES | CCCCC[C@H](O)C/C=C([C@@H](C/C=C\CCCC(O)=O)C=C1)/C1=O |
| 分子式 | C20H30O4 |
| 分子量 | 334.5 |
| 溶解度 | DMF: >100 mg/ml (from PGD2),DMSO: >50 mg/ml (from PGD2),Ethanol: >75 mg/ml (from PGD2),PBS pH 7.2: >2.7 mg/ml (from 15-deoxy-d12, |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | δ12-PGJ2 is a decomposition product of PGD2 in aqueous media in the presence of albumin. It has antitumor and antiviral activity, inhibiting growth of cultured L1210 cells at with an IC50 value of 0.7 µg/ml. δ12-PGJ2 is present in normal human urine with a 24 hour excretion rate of 50-150 ng. It is also a moderately potent PPARγ ligand. |
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