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Glucocorticoid Resistance Inhibitor
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Glucocorticoid Resistance Inhibitor图片
CAS NO:947018-15-7
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Cas No.947018-15-7
Canonical SMILESNC1=NC(C2CC2)=C(C3=CC=NC=C3)C=N1
分子式C12H12N4
分子量212.3
溶解度DMF: 5 mg/ml,DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml,DMSO: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Glucocorticoid resistance inhibitor is an inhibitor of glucocorticoid resistance. It inhibits cell growth of the T cell acute lymphoblastic leukemia (T-ALL) cell line CUTTL1 when used in combination with dexamethasone (EC50 = 28 µM) and is less effective when used alone (EC50 = 294 µM). Glucocorticoid resistance inhibitor (6.25-50 µM) preferentially inhibits growth of CUTTL1 cells expressing high levels of the glucocorticoid receptor over cells expressing low levels. It upregulates the gene expression and protein levels of the glucocorticoid receptor and induces expression of dexamethasone-regulated genes when used in combination with dexamethasone but not when used alone.