CAS NO: | 521-49-3 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
Cas No. | 521-49-3 |
别名 | 2,3-二氢-2,3,3-三甲基萘并[1,2-B]呋喃-4,5-二酮 |
化学名 | 2,3-dihydro-2,3,3-trimethyl-naphtho[1,2-b]furan-4,5-dione |
Canonical SMILES | O=C(C1=CC=CC=C1C2=C3C(C)(C)C(C)O2)C3=O |
分子式 | C15H14O3 |
分子量 | 242.3 |
溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | (±)-Dunnione is a naturally occurring naphthoquinone with diverse biological activities.[1][2][3][4] It exhibits fungicidal activity against ten agriculturally relevant plant fungi in vitro (MICs = 5-20 mg/L) and in infected wheat and barley plants (EC50s = 2-20 mg/L)[1]. (±)-Dunnione also reduces the growth of T. cruzi epimastigotes (IC50 = 4.01 μM)[2]. It is a substrate for NAD(P)H:quinone oxidoreductase 1 (NQO1) that increases production of reactive oxygen species (ROS) and induces cell death of A549 lung carcinoma cells (IC50 = 6.1 μM).[3] (±)-Dunnione (20 mg/kg per day for 4 days) increases intracellular NAD+ and prevents inflammatory cytokine production and small intestinal damage induced by cisplatin in mice.[4] Reference: [1]. Khambay, B.P.S., Batty, D., Jewess, P.J., et al. Mode of action and pesticidal activity of the natural product dunnione and of some analogues Pest. Manag. Sci. 59(2), 174-182 (2003). |