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Pregnanediol-3-Glucuronide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Pregnanediol-3-Glucuronide图片
CAS NO:1852-49-9
包装与价格：
包装价格(元)
500μg电议
1mg电议

产品介绍
Pregnanediol-3-Glucuronide 是孕酮的主要终末代谢物，在人类和其他物种的女性月经周期、妊娠（支持妊娠）、胚胎发生和母体免疫反应等生理过程中发挥着重要作用。
Cas No.1852-49-9
别名Pregnanediol-3α-Glucuronide
化学名(3α,5β,20S)-20-hydroxypregnan-3-yl, β-D-glucopyranosiduronic acid
Canonical SMILESC[C@@]12[C@@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@]4([C@H](C)O)[H])([H])C[C@H](O[C@]5([H])O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]5O)CC1
分子式C27H44O8
分子量496.6
溶解度20mg/mL in ethanol
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Pregnanediol-3-glucuronide (PDG) is the primary urinary metabolite of the steroid hormone progesterone。 [1] Levels of PDG in the urine correlate to levels of progesterone measured in the serum.[1] [2] Analysis of urinary PDG has been used to detect ovulatory and anovulatory menstrual cycles in women as well as to assess the fertility of ovulatory cycles.[3] [4]

Reference:
[1]. O'Connor, K.A., Brindle, E., Holman, D.J., et al. Urinary estrone conjugate and pregnanediol 3-glucuronide enzyme immunoassays for population research. Clin. Chem. 49(7), 1139-1148 (2003).
[2]. Munro, C.J., Stabenfeldt, G.H., Cragun, J.R., et al. Relationship of serum estradiol and progesterone concentrations to the excretion profiles of their major urinary metabolites as measured by enzyme immunoassay and radioimmunoassay. Clin. Chem. 37(6), 838-844 (1991).
[3]. Kassam, A., Overstreet, J.W., Snow-Harter, C., et al. Identification of anovulation and transient luteal function using a urinary pregnanediol-3-glucuronide ratio algorithm. Environ. Health Perspect. 104(4), 408-413 (1996).
[4]. Blackwell, L.F., Cooke, D.G., and Brown, S. The use of estrone-3-glucuronide and pregnanediol-3-Glucuronide Excretion Rates to Navigate the Continuum of Ovarian Activity. Front. Public Health 6:153, (2018).