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Tamoxifen N-oxide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tamoxifen N-oxide图片
CAS NO:75504-34-6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Cas No.75504-34-6
别名他莫昔芬N-氧化物
Canonical SMILESCC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)(C)=O)C=C3
分子式C26H29NO2
分子量387.5
溶解度DMF: 20 mg/mL,DMSO: 2 mg/mL,Ethanol: 20 mg/mL,Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tamoxifen is a selective estrogen receptor modulator that evokes tissue-dependent effects. Tamoxifen N-oxide is a metabolite of tamoxifen that is produced by the action of flavin-containing monooxygenases. It can be converted back to tamoxifen by cytochrome P450 isoforms and hemoglobin. Like the parent compound, tamoxifen N-oxide can form DNA adducts. Tamoxifen N-oxide is a weak inhibitor of human hydroxysteroid sulfotransferase 2A1 (Kis = 9.1 and 16.9 µM for the sulfonation of dehydroepiandrosterone and pregnenolone, respectively).