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PROTAC RAR Degrader-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
PROTAC RAR Degrader-1图片
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
PROTACRARDegrader-1包含cIAP1配体结合基团，linker和RAR配体结合基团。在HT1080细胞中，PROTACRARDegrader-1降低RAR水平，30μM浓度时达到最大降解程度。同时，基于cIAP1的降解剂也被称为SNIPER。
Canonical SMILESN[C@@H]([C@@H](C(N[C@@H](CC(C)C)C(NNCCOCCOCCC(NCCCOC1=CC(/C=C/C(C2=CC(C(C)(C)C)=CC(C(C)(C)C)=C2)=O)=CC=C1C(O)=O)=O)=O)=O)O)CC3=CC=CC=C3
分子式C50H71N5O10
分子量902.13
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PROTAC RAR Degrader-1 comprises a cIAP1 ligand binding group, a linker and a RAR ligand binding group. PROTAC RAR Degrader-1 is an RAR degrader. Maximal RAR degradation at 30 μM concentration in HT1080 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].

[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176.